Tel: +44 (0) 1235 56 7480
E-mail: [email protected]
Peijun Zhang
Tel: +44 (0) 1235 77 8878
E-mail: [email protected]
Daniel Clare
Tel: +44 (0) 1235 56 7501
E-mail: [email protected]
Yuriy Chaban
Tel: +44 (0) 1235 77 8207
E-mail: [email protected]
Karen Davies
Tel: +44 (0) 1235 77 8057
E-mail: [email protected]
Tel: +44 (0) 1235 39 4182
E-mail: [email protected]
Email: [email protected]
Tel: +44 (0)1235 778518
The electron Bio-Imaging Centre was established at Diamond Light Source following the award of a £15.6 million grant from the Wellcome Trust, the Medical Research Council (MRC) and the Biotechnology and Biological Sciences Research Council (BBSRC).
eBIC mission:
eBIC is a CryoEM center providing scientists with state-of-the-art experimental equipment and expertise in the field of cryo-electron microscopy, for single particle analysis, electron tomography and electron diffraction. The location of eBIC enables scientists to combine their techniques with many of the other cutting-edge approaches that Diamond offers.
Currently eBIC houses five Titan Krios microscopes, a Talos Arctica, two Glacios, a Scios and an Aquilos cryo-FIB/SEM, and a Leica CryoCLEM.
Access to eBIC is available and currently operating under general beamline guidelines.
We are able to offer remote access, unattended automated data collection (currently only available: data collection using TFS EPU and TFS Tomography) and sample mail-in services for all research areas.
COVID-19 research should be requested through rapid access proposals following these instructions.
NOTE: Diamond EHC +44 (0)1235 778787 are available for support providing 24-hour coverage during the week when the beamline is on. Over the weekend EHC coverage is for 12hours only from 7am-7pm Sat & Sun.
We now have an opportunity at group-leader level for a Principal EM Scientist to underpin and further develop eBIC as a leading centre for cryoEM. eBIC together with B24, which provides a full-field cryo X-ray transmission microscope and a bespoke 3D super resolution fluorescence cryo-imaging microscope, makeup the Biological Cryo-Imaging group at Diamond. We work closely with the Imaging and Microscopy group at Diamond, in particular ePSIC, the physical sciences electron imaging centre. We provide an extraordinarily strong imaging platform for using electrons, X-rays and visible light to image a diverse range of samples across a range of length and time scales.
As a Principal EM Scientist at eBIC you will lead a small team of scientists to establish a competitive research programme which exploits the capabilities of eBIC and Diamond in general and to take part in the management of the operation, maintenance, and development of eBIC. We are particularly keen to attract applicants with an interest in cryo-ET and correlative imaging.
Read more here...Principal Electron Microscopy Scientist
We are seeking a highly motivated PDRA on a 16 month fixed term contract to develop and apply a multi-scale and correlative microscopy workflow to understand the germicidal effects of anti-microbial agents on microorganisms. This is a collaboration between Procter & Gamble and the Diamond Light Source. You will use optical microscopes (cryoSIM and Leica cryoCLEM), cryo-Soft X-ray Tomography (SXT), with Scios/Aquilos cryoFIB/SEM instrument and Krios microscopes at Diamond and set up novel experiments to investigate how individual antimicrobial agents (AMA) affect the cell (e.g. peroxidation, lipid plasticisation, chelation of multivalent cations bound to the lipids and permeation of small molecules through it) and to identify the best combination for fast kill.
Read more here...Postdoctoral Research Associate - Correlative Microscopy
A postdoc position is available in Professor Zhang’s lab at the Electron Bio-Imaging Centre (eBIC), Diamond Light Source, UK. The post is funded by a DoD award on “Characterization of a novel class of non-competitive androgen receptor antagonists”.
Castration-resistant prostate cancer (CRPC) is currently incurable and is the second leading cause of cancer death in American men. Androgen-independent activation of the androgen receptor (AR) remains the major driving force leading to CRPC. Structural and functional analysis of a novel class of AR antagonists capable of inducing AR degradation in the nucleus may lead to new therapeutics for CRPC. The posts will take part in the collaborative team research to understand the underlying molecular mechanisms of the inhibition and degradation of nuclear AR by this class of antagonists using structural biology approaches.
We are seeking highly motivated scientist to conduct high-resolution structural analysis of AR in complexes with its antagonists. The post is based in eBIC, the UK national cryoEM facility, which provides scientists with state-of-the-art instruments and expertise in cryoEM. Currently eBIC houses five Titan Krios, a Talos Arctica, and two Glacios, two cryoFIB/SEM instruments (Scios and Aquilos 2), and a Leica cryoCLEM for correlative light and electron microscopy.
Read more here...PDRA - Characterization of androgen receptor antagonists
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